National Dental Examining Board of Canada (NDEB) Practice Exam

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What is the therapeutic advantage of penicillin V over penicillin G?

  1. Longer half-life

  2. Greater absorption when given orally

  3. Higher potency

  4. More effective against gram-negative bacteria

The correct answer is: Greater absorption when given orally

While penicillin G is considered the gold standard for the treatment of many infections, one of the main limitations of this antibiotic is that it can only be given intravenously or intramuscularly. On the other hand, penicillin V has a greater ability to be absorbed when taken orally, making it an advantageous option for patients who are unable to receive injections. Penicillin V also has a similar spectrum of activity as penicillin G, making it just as potent, and it is equally effective against gram-positive bacteria. Therefore, penicillin V's therapeutic advantage lies in its ability to be taken orally, making it a more convenient and accessible treatment option for patients. The other options (A, C, and D) are all incorrect because they do not provide a clear therapeutic advantage of penicillin V over penicillin G. Option A refers to the half-life,

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