National Dental Examining Board of Canada (NDEB) Practice Exam

  • Session length

Which penicillin is least resistant to the level of acidity in the stomach?

Ampicillin

Amoxicillin

Benzylpenicillin

The reason why the other options are incorrect is because ampicillin, amoxicillin, and cloxacillin are all semi-synthetic penicillins and thus have been chemically modified to be more resistant to stomach acid. Cloxacillin, in particular, has a side chain that makes it more resistant to stomach acid. However, benzylpenicillin is not a semi-synthetic penicillin and has no additional modifications to make it more resistant to stomach acid. Therefore, it is the least resistant to the acidic conditions in the stomach.

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Cloxacillin

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